Curcumin
Curcumin is a polyphenol compound found in turmeric that has been shown to have anti-inflammatory and antioxidant properties. Curcumin has been the subject of numerous research studies reported worldwide regarding its efficacy. However, even when curcumin is orally administered at a high dose, only a small quantity of curcumin is detected in the blood plasma. Additionally, almost all curcumin in plasma is metabolized into conjugates and rapidly excreted from the body.
Highly Absorbable Curcumin = curcuRouge®
We have developed “curcuRouge®” using our proprietary manufacturing process and technology (amohrphous tehcnology), and have succeeded in significantly improving the low absorption of curcumin. In a Published Study, the absorption of curcuRouge® in the body has been shown to be approximately 100 times higher compared with regular curcumin and over five times higher absorption compared to commercially available high-absorption products.
You can find more information of curcuRouge® with this link.
Dispersal of curcuRouge® in Water
Characteristics of curcuRouge®: Red Curcumin
The distinctive reddish orange color of "curcuRouge®" is created through our company's proprietary production technology to dramatically enhance absorption resulting in the transformation of yellow curcumin into reddish orange. It serves as evidence of its high absorbability.
crucumin
curcuRouge®
Comparison of solubility of curcumin and various curcumins in water
curcuRouge® shows the highest solubility in water among various curcumin products.
In vivo comparison among synthesized curcumin, Theracurmin and curcuRouge® ( absorbent comparison in animals)
cucuRouge® shows higher bioavailability than other curcumin products at in vivo study to administer curcumin to rats.
The world's strongest highly absorbent curcumin
Confirmation of high absorption of curcuRouge® preparation in human test
(Crossover randomized control trial)
curcuRouge is 3.4 times higher in AUC and 5.4 times higher in maximum blood concentration than Theracurumin, indicating that more curcumin is absorbed in the body.
Study design:
Randomized double-blind two-way crossover study
Target audience:
12 healthy people aged 19 to 60
Reference:
A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: A single-dose,
double-blind, two-way crossover study
Journal of Function Foods 81 (2021)104443
What is AUC (area under the blood concentration time curve)?
AUC is the approximate amount of active ingredient taken into the body. It is a graphical representation of how the blood concentration changes after taking it, and the area under the graph is calculated. This area is considered to be the total amount of the ingredient taken up by the body. If this value is high, it is considered hat the body has taken in more.
What is Cmax
(maximum blood concentration) ？
The maximum blood concentration (Cmax) is the highest concentration of an active ingredient in the blood.
Excellent characteristics of curcuRouge®:
High-speed passage through the blood-brain barrier and fast penetration into the brain
(10mg/kg oral dose for rats, in vivo)
When rats were orally administered curcumin at a dose of 10 mg per kg of body weight, curcumin was observed to cross the blood-brain barrier and migrate to the brain in the curcuRouge®-treated group.
curcuRouge® research report
Scientific evidences of curcuRouge® were reported at the Japan Pharmaceutical Meeting (held in 2024).
These are the summary of results. Please check this link for more detailed information.
• Immune function: Improvements in immune indices were observed in healthy individuals over 60 years of age.
• COVID-19 Infection: The possibility of reducing the progression of symptoms in mildly infected patients was confirmed.
• Heart failure (animal test) ：The effect of improving cardiac function was reported when administered to rats that had suffered myocardial infarction.
• knee osteoarthritis: Patients in early and advanced stages reported less pain and inflammation.
Reliable quality:
No red yeast rice or similar substances are used in manufacture of curcuRouge®. Also, there is no fermentation in the manufacturing process.
curcuRouge®（62 capsules/bottle)
To make it easy to take “curcuRouge®”, we have launched a product that contains the required amount in small capsules.
Try our curcuRouge® and feel the difference!
Prices are 7,560 JPY per bottle, 19,278 JPY for a set of three, and 30,240 JPY for a set of five (all tax included, shipping within Japan and paid by the company).
How to Purchase
Please select one of the following purchase methods
■Order from the “Shop” tab on this website (credit card accepted)
■ Order by e-mail (payment by bank transfer only)
Please send an e-mail to rouge@therabio.co.jp with the subject line “Purchase Request” for curcuRouge®” and the following information in the body of the e-mail.
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Name
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Number of crucuRouge® to purchase
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Address to which the goods will be sent
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Zip code
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Telephone number
■ Contents: 62 capsules (for approximately 30 days, 390 mg per capsule, of which 90 mg is curcumin)
■ Recommended daily amount: 2 capsules
■ Ingredients: Turmeric extract (manufactured in Japan), cornstarch/processed starch, HPMC, calcium stearate
■ Nutrition Facts per 2 capsules (780mg)
Calories/3.60kcal, Protein: 0g, Fat: 0.12g, Carbohydrate: 0.63g, Salt equivalent: 0.001g, Curcumin: 180mg
■ Directions for use
Take 2 capsules per day with water or other liquids.
■ Precautions for use
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Consult your doctor if you take medication or visit the hospital, or if you are pregnant or nursing.
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Because plant-derived ingredients are used, the color may change in rare cases, but this does not affect quality.
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After opening the package, close the lid tightly and store in cool and dry place and consume as soon as possible.
Contents, Ingredients, and Precautions for curcuRouge® Capsules